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Dronabinol (nabiximols; Sativex) is a delta-9-THC and cannabidiolattieneicetylindole cannabinoid preparation developed by GW Pharmaceuticals in the United Kingdom for treating spasticity due to multiple sclerosis or other causes.[23] It contains 2.5 mg of THC and 7.5 mg of CBD in each 10 mL vial, making it available as 5 separate softgel capsules at twice daily doses.[24] Dronabinol’s active ingredients were approved by the FDA on January 15, 2002,[25] by Europe on March 27, 2003[26], and in Canada on June 29, 2004.[27][28][29][30] In contrast with most other cannabinoids that are listed under Schedule I of the Controlled Substances Act,[31] nabilone has a high potential for abuse relative to its use as an antidepressant[32]:429–37 [33]:1499 [34]:1125 [35]:1386[36]:2158–2169 [37].